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Dr. Ying-Hui Fu (傅嫈惠)

Professor of Neurology

Department of Neurology, University of California at San Francisco, CA, USA

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My research focus has been using human genetics to identify mutations that contribute to neurological conditions and sleep behaviors and then to characterize the corresponding wild-type and mutant proteins. Animal models including mouse and fly are used to recapitulate human conditions via the generation of mutation-carrying animals. In addition, in vitro experiments using cell culture, cellular biology, biochemistry, and proteomics are applied to gain understanding of new aspects of normal biology as well as molecular mechanisms of diseases and unusual sleep behaviors. Each gene that we identify provides new insights into the overall mechanism of complex pathways involved in each condition. This approach has been extremely fruitful for us in revealing the regulatory pathways of human sleep behaviors. The dominant mutations that we have identified in human repeatedly provide significant and unique insights into these pathways that could not be obtained using other traditional animal modeling approaches. To further deepen our understanding of the regulatory mechanisms of human sleep duration and efficiency at the neuro-circuitry level, we are applying emerging neuroscience technologies in our research. This will significantly expand the potential for reaching our ultimate goal of helping people obtain better health and better aging through better sleep.

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