Rare human hereditary disorders provide unequivocal evidence of the importance of genes in human disease pathogenesis and offer powerful insights into their roles in human disease pathogenesis. Prof. Lee's research is dedicated to understanding cancer pathological mechanisms by iPSC disease models. As a biomedical investigator, with a significant background and training in stem cell and cancer biology, he has been fortunate enough to design and merge his laboratory research and clinical interests. Dr. Lee recognizes the need for improving our understanding of osteosarcomagenesis and the identification of therapeutic agents for patient treatment. His laboratory has tremendous interest and experience in collaborating clinical physicians to merge innovative iPSC disease models and patient-derived resources such as PDXs, patient specimens, and TCGA database, towards garnering molecular insights into osteosarcoma initiation, development and therapeutic resistance and translating these findings towards testing novel therapeutic interventions for these bone malignancies.